VAXELIS (DTaP/IPV/Hib/Hep B) is a hexavalent vaccine indicated for primary and booster vaccination in infants and toddlers from the age of 6 weeks, against diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis and invasive disease caused by Haemophilus influenzae type b (Hib). 1
VAXELIS contains 5 acellular pertussis components to effectively elicit seroprotection when used in a series of primary vaccinations. The Hib PRP-OMPC conjugate used in VAXELIS elicits earlier Hib protective responses than PRP conjugated to tetanus toxoid.2,3
VAXELIS is also the fully liquid hexavalent vaccine with a Luer-lock syringe, helping to reduce preparation time and potentially preparation errors.1, 4-6
VAXELIS Prescribing information
VAXELIS is the result of a U.S.-based joint-partnership established in 1991 between Merck & Co, Inc and Sanofi Pasteur, the vaccines unit of Sanofi, and draws upon both companies' experience in the development, manufacturing and marketing of individual and combination vaccines.
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Presentation |
0.5 mL suspension for injection in pre-filled syringe. |
Posology |
Primary schedule: Two or three doses with at least one month between doses. Primary vaccination schedule should be given in accordance with the official recommendations. Booster: After two-dose or three-dose primary series, a booster should be given at least six months after the last priming dose. Booster dose should be given in accordance with the official recommendations. As a minimum, a dose of Hib vaccine must be administered. |
Age range |
May be given from 6 weeks of age. |
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Please note that the current UK routine childhood immunisation schedule does not include a booster dose after the initial 3 vaccinations at 8, 12 and 16 weeks old.
*The comparator group received DTPa3-HBV-IPV/Hib
References:
Before you prescribe this vaccine, please refer to the Prescribing Information and Summary of Product Characteristics links below.
VAXELIS is suitable for use as part of the UK infant immunisation schedule at 8, 12 and 16 weeks old.
Primary vaccination:
The primary vaccination schedule consists of two
or
three doses, with an interval of at least 1
month
between doses, and may be given from 6 weeks of
age,
in accordance with the official recommendations.
Booster vaccination:
After a 2-dose or a 3-dose primary series
vaccination with Vaxelis, a booster dose should
be
given at least 6 months after the last priming
dose.
The booster dose should be given in accordance
with
official recommendations. As a minimum, a dose
of
Hib vaccine must be administered.1
VAXELIS can be given concomitantly
with:1
*Clinical data indicate that when VAXELIS is co-administered with pneumococcal conjugate vaccine (PCV13), the rate of fever is higher following the booster dose in the second year of life compared to the primary series; almost all fevers were mild or moderate and transient.1
Refer to the SmPC for more information.
VAXELIS Prescribing information
NHS Start4Life – Your baby’s vaccination schedule
UK Routine Immunisation Schedule
References:
Date of preparation: January 2022 | MAT-GB-2105621(v1.0)