Intended for UK healthcare professionals

Basics

Flu just met its
genetic match

Introducing Supemtek
Recombinant technology
Efficacy
Comparison versus standard influenza vaccines

FLU JUST MET ITS GENETIC MATCH

Supemtek is included in latest 2022/23 Joint Committee on Vaccination and Immunisation (JCVI) recommendations for all eligible adult cohorts.1

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MORE INFO

Target influenza with Supemtek (Quadrivalent Influenza Vaccine, recombinant prepared in cell-culture), the first recombinant influenza vaccine in Europe. Supemtek is manufactured to offer an exact genetic match to the World Health Organization (WHO)-predicted viral strains.2,3

Supemtek Prescribing Information

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Supemtek quadrivalent influenza vaccine is indicated for active immunisation for the prevention of influenza disease in adults.2

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Supemtek's clinical data and safety profile

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and safety profile.

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THE UNDERESTIMATED THREAT OF INFLUENZA

A recent, self-controlled case series study showed that adults aged ≥40 years (median age of
68 years), without a history of heart attack or stroke, were at an increased risk of severe cardiovascular complications in the 1–3 days following a confirmed influenza infection.*4

Patients were at a 10x increased risk of a first heart attack and 8x increased risk of a first stroke.*4

Each year in the UK, influenza vaccination could help to reduce the number of influenza cases
and influenza-related premature deaths.5

INTRODUCING SUPEMTEK

RECOMBINANT TECHNOLOGY

Recombinant technology eliminates the possibility of adaptation or mutation by replicating only the haemagglutinin (HA) antigen direct from a genetic sequence. The resulting antigens are an exact genetic match to the target strain HA antigen.3,6

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INCREASED HA CONTENT

Supemtek contains 3x more HA antigen (45 mcg versus 15 mcg) per strain, compared with cell-
and egg-based standard-dose quadrivalent influenza vaccines.3

EFFICACY

Supemtek demonstrated 30% greater relative efficacy (1% absolute efficacy) versus standard-dose egg-based quadrivalent inactivated influenza vaccine (QIVe), in preventing confirmed cases of influenza-like illness in adults ≥50 years of age, with respective influenza attack rates of
2.2% and 3.2 %.†3

Find out more about the clinical data for Supemtek here

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COMPARABLE SAFETY PROFILE

Supemtek demonstrated a comparable safety profile to standard-dose egg-based QIVe.3,7

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SUPPORTED BY RANDOMISED CONTROLLED TRIALS

Randomised controlled trials support the efficacy and safety of Supemtek for active immunisation for the prevention of influenza disease in adults ≥18 years of age.3,7

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COMPARISON VERSUS STANDARD INFLUENZA VACCINES

Results from a European Centre for Disease Prevention and Control (ECDC) systematic literature review to assess the efficacy, effectiveness and safety of enhanced influenza vaccines (versus standard-dose or placebo) for the prevention of laboratory-confirmed influenza in adults ≥18 years of age suggested that Supemtek may offer ”better protection than no vaccination, or standard influenza vaccines.”(QIVe)8

Find out more about the results of the review here

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*As measured by age- and season-adjusted incidence ratios for myocardial infarction (n=1,227) or stroke (n=762) in adults aged 40 years or older, in the 1-3 days following a laboratory-confirmed influenza infection. Adjusted IRs were 9.80 (95% CI: 2.37, 40.5) and 7.82 (95% CI: 1.07, 56.9) for myocardial infarction and stroke, respectively.4

As measured by relative vaccine efficacy (rVE) in adults aged 50+ years, randomised 1:1 to receive single dose of Supemtek (n=4,303) or standard-dose egg-based QIVe (n=4,301) during the 2014/15 influenza season (95% CI: 10, 47 p=0.006). Influenza attack rates were 2.2.% and 3.2% for Supemtek and standard-dose QIVe, respectively. The lower bound (LB) of the 95% confidence interval met the pre-specified, exploratory criterion for superior rVE LB >9%. Primary endpoint: rVE against reverse transcription polymerase chain reaction-confirmed, protocol-defined, influenza-like illness caused by any influenza strain starting 14 days or more after vaccination.3

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CI, confidence interval; ECDC, European Centre for Disease Prevention and Control; HA, haemagglutinin; JCVI, Joint Committee on Vaccination and Immunisation; LB, lower bound; QIVe, quadrivalent inactivated influenza vaccine; rVE, relative vaccine efficacy; WHO, World Health Organization.

REFERENCES:
  1. Joint Committee on Vaccination and Immunisation (JCVI). Advice on influenza vaccines for 2022/23. https://app.box.com/s/t5ockz9bb6xw6t2mrrzb144njplimfo0/file/863135232161 [Last accessed January 2022].
  2. Supemtek Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/12761/smpc#gref.
    [Last accessed January 2022].
  3. Dunkle LM, et al. N Engl J Med. 2017;376:2427–36.
  4. Warren-Gash C, et al. Eur Resp J. 2018;51:1701794.
  5. Franklin B and Hochlaf D. An economic analysis of flu vaccination. https://ilcuk.org.uk/wp-content/uploads/2018/07/An_economic_analysis_of_flu_vaccination_-_ILC-UK.pdf [Last accessed January 2022].
  6. Centers for Disease Control and Prevention. How influenza (flu) vaccines are made. https://www.cdc.gov/flu/prevent/how-fluvaccine-made.htm#recombinant [Last accessed January 2022].
  7. Dunkle LM, et al. J Infect Dis. 2017;216:1219–26.
  8. ECDC (2020) Systematic review of the efficacy, effectiveness, and safety of newer and enhanced seasonal influenza vaccines for the prevention of laboratory-confirmed influenza in individuals aged 18 years and over. https://www.ecdc.europa.eu/sites/default/files/documents/seasonal-influenza-vaccines-systematic-review-efficacy.pdf [Last accessed January 2022].

Date of preparation: January 2022 | MAT-GB-2003349(v4.0)